Esra Tasali, M.D., Director, Sleep Research Center

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Associate Professor of Medicine
Section of Pulmonary/Critical Care Medicine and Section of Endocrinology, Diabetes & Metabolism
Department of Medicine

Esra Tasali, MD is an internationally recognized expert in the study of sleep disturbances as they relate to metabolic diseases. She has made important contributions to our understanding of the mechanistic pathways linking reduced sleep duration and quality to increased risk of diabetes and obesity. Her innovative research has demonstrated that experimental reductions in sleep quality adversely affects glucose homeostasis and may increase the risk for diabetes. Her work also demonstrated that sleep duration is an important regulator of neuroendocrine hormones and energy metabolism in peripheral tissues. Additionally, Dr.Tasali’s studies examine how the experimental laboratory findings could be translated into clinical practice in individuals with insufficient sleep and sleep disorders such as sleep apnea. Her work has significantly contributed to our understanding of the links between sleep apnea and glucose metabolism. She has also demonstrated that healthy sleep habits can be successfully implemented in real life settings. Over the past decade, she has led as a principal investigator multidisciplinary research projects funded by the National Institute of Health to investigate the effects of sleep and sleep disorders on metabolic function.


Vineet Arora, M.D., M.A.P.P.

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Associate Professor of Medicine
Section of General Internal Medicine
Assistant Dean for Scholarship and Discovery
Director of GME Clinical Learning Environment Innovation

Vineet Arora, MD, MAPP, is an academic hospitalist whose interest in sleep began as a chief resident working to adapt the inpatient services to meet pending resident duty hour restrictions. With this natural experiment, she rigorously documented the effectiveness of a night float intervention on resident sleep, fatigue and patient care. Her work is featured in an Institute of Medicine report and led to systematic reviews of the impact of the 2003 duty hours on resident health and patient outcomes which informed the 2011 resident duty hour restrictions. In 2009, with NIH/NIA funding, she turned her attention to hospitalized patients and has objectively demonstrated the acute sleep deprivation and unsafe noise levels for inpatients, and its association with cardiometabolic derangements. With NHLBI funding, she developed SIESTA, an intervention based on adult learning theory and behavioral economic principles, to nudge hospital staff to reduce unnecessary sleep disruptions for their patients.


Matthew Brady, Ph.D.

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Associate Professor of Medicine
Section of Endocrinology and Metabolism
Chair, Committee on Molecular Metabolism and Nutrition
Department of Medicine

Matthew Brady, PhD, is an Associate Professor of Adult and Pediatric Endocrinology, Diabetes and Metabolism at the University of Chicago, and is Vice Chair of the Committee on Molecular Metabolism and Nutrition in the Biological Sciences Division. He also has been appointed to the Committee on Molecular Pathogenesis and Molecular Medicine and to the Committee on Cell Physiology. His research focuses on the relationship between metabolism, diabetes and lipid (fat) storage. The overall focus of his lab is metabolic signaling.  Dr. Brady is particularly interested in the insulin-mediated regulation of energy storage in adipocytes and hepatocytes, the interplay of glucose and lipid metabolism, the regulation of hepatic glucose production, and the molecular mechanisms underlying the development of insulin resistance in animal models and humans. His research is conducted using cell lines, primary murine hepatocytes and adipocytes, and samples collected from human fat biopsies.

Dr. Brady has served as a reviewer for 17 medical journals including Diabetes, the Journal of Biochemistry and Obesity Research. He has published more than 45 research articles in peer-reviewed journals and has presented seminars at universities and medical institutions worldwide. Dr. Brady also has served on numerous grant review panels for the National Institutes of Health. Among his current research are projects focused on hormonal regulation of energy metabolism and the effects of modulating sleep patterns on insulin Sensitivity in human adipose tissue.


Jason Carter, Ph.D.

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Visiting Scholar
Professor and Chair of Kinesiology and Integrative Physiology
Michigan Technological University
Dr. Carter is a Visiting Scholar with the Sleep Research Center (SRC), and is currently on sabbatical from his home institution of Michigan Technological University, where he serves as Professor and Chair of Kinesiology and Integrative Physiology. His research interest is neural control of circulation in humans, and he is an international expert in the technique of microneurography. This invasive procedure is considered a gold-standard approach for assessing sympathetic activity, and remains the only direct measure of post-ganglionic sympathetic neural activity in humans.
Dr. Carter’s current research focuses on the impact of sleep deprivation, insomnia, and sleep apnea on blood pressure and sympathetic neural control. Much of this research also focuses  on potential differences that exist between men and women. His group has recently shown that total sleep deprivation elicits differential sympathetic neural responses in men and women, an controlled laboratory finding that provides new mechanistic insight on epidemiological studies that have reported stronger associations between short sleep and hypertension in women compared to men.
Dr. Carter serves on the editorial board for the American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology, is an Executive Committee member for the American Kinesiology Association, and is past-president of the Michigan Physiological Society.

 


Arlene Chapman, M.D.

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Professor of Medicine
Chief, Section of Nephrology
Department of Medicine

Dr. Chapman’s research focuses on mechanisms of cyst formation in autosomal dominant polycystic kidney disease and determinants of genetic contributions to antihypertensive drug responses in essential hypertension. Her early investigations also centered on renal and systemic hemodynamic changes that occur during normal and pre-eclamptic pregnancies. With continuous NIH funding for the past 15 years, Dr. Chapman has established that through magnetic resonance imaging, significant changes in renal and liver cyst burden can be detected over a short period of time in autosomal dominant polycystic kidney disease so that novel therapies can be tested. These advances have led to the testing of promising new agents in ADPKD including Vasopressin V2 receptor antagonists as well as formally testing inhibition of the renin-angiotensin-aldosterone system in ADPKD patients with hypertension. In addition, Dr. Chapman has established novel genetic contributors to antihypertensive responses to thiazide diuretics and B-blocker therapy in patients with uncomplicated essential hypertension.


David Ehrmann, M.D.

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Professor of Medicine
Section of Endocrinology and Metabolism
Department of Medicine

Dr. David Ehrmann specializes in the diagnosis and treatment of polycystic ovary syndrome (PCOS). He is also an expert in type 2 diabetes.

His research interests include the role that hereditary factors play in the development of PCOS, the use of insulin-sensitizing agents in the treatment PCOS, and the relationship between PCOS and obstructive sleep apnea.

Dr. Ehrmann has written more than 60 medical publications–including book chapters, articles, and abstracts. He has been on numerous national committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and the American Journal of Physiology.


Erin Hanlon, Ph.D.

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Research Associate (Assistant Professor)
Professor of Medicine
Section of Endocrinology and Metabolism
Department of Medicine
Erin C. Hanlon, PhD. is currently a Research Associate in the rank of Assistant Professor in the section of Endocrinology.  As a behavioral neuroscientist, she is interested in the relationship between behavior, brain mechanisms, and physiology that may impact human health. Her Primary research interests include the detrimental effects of sleep loss and how sleep benefits health. In particular, her focus is on the effect of sleep restriction on brain reward and feeding systems as well as peripheral metabolic systems in both rodent and human models. She has extensive experience administering and analyzing behavioral tasks, PSG, and metabolic measures in both rodent and human models.

 


Babak Mokhlesi, M.D., M.Sc.

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Professor of Medicine
Section of Pulmonary and Critical Care Medicine
Director, Sleep Disorders Center
Department of Medicine

Dr. Babak Mokhlesi is a pulmonologist and an expert in sleep disorders. He is director of the Sleep Disorders Center and Sleep Medicine Fellowship program. He treats patients with a wide variety of sleep disorders, ranging from respiratory disorders of sleep — such as sleep apnea and obesity hypoventilation syndrome — to non-respiratory sleep disorders including narcolepsy, restless leg syndrome, parasomnias, circadian rhythm disorders and insomnia. In his practice, Dr. Mokhlesi cares for patients in clinic as well as in the intensive care unit.

During the last few years, his research has focused on obstructive sleep apnea, with a specific focus on REM-related sleep-disordered breathing, perioperative complications in patients with sleep apnea, as well as best treatment strategies in patients with obesity hypoventilation syndrome. He is also interested in studying the impact of continuous positive airway pressure (CPAP) therapy on metabolic and cardiovascular outcomes in obstructive sleep apnea.

In addition to authoring several book chapters and articles, Dr. Mokhlesi is a reviewer for the journals Chest, American Journal of Respiratory and Critical Care Medicine, Critical Care Medicine, Intensive Care Medicine, Sleep, and the Journal of Clinical Sleep Medicine. He also sits on the editorial board of Chest and the Proceedings of the American Thoracic Society.


Silvanna Pannain, M.D.

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Associate Professor of Medicine
Section of Endocrinology and Metabolism
Department of Medicine

Dr. Pannain’s clinical and research interests include obesity, metabolic syndrome and related health conditions, such as obstructive sleep apnea and diabetes. She investigates the metabolic and endocrine aspects of chronic partial sleep loss, which is generally considered a risk factor for obesity and insulin resistance. Additionally, she is studying the effects of gastric bypass surgery on metabolism, sleep and hunger.


Susan Sam M.D., M.Sc.

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Assistant Professor of Medicine
Section of Endocrinology and Metabolism
Department of Medicine

Dr. Sam is an adult endocrinologist who specializes in the diagnosis and treatment of polycystic ovary syndrome (PCOS). She also has a clinical interest in other reproductive disorders leading to menstrual irregularity in women, type 2 diabetes and related metabolic disorders.

Dr. Sam’s research focuses on the metabolic abnormalities associated with PCOS such as the high risk for development of type 2 diabetes, lipid disorders and obesity. In particular she examines how abnormalities in fat tissue such as inflammation lead to development of insulin resistance in PCOS. She has received prestigious research grants and has published her findings in a number of scientific journals, including Proceedings of the National Academy of Sciences, Diabetes, Diabetes Care, and the Journal of Clinical Endocrinology and Metabolism.

She serves as a manuscript reviewer for scientific journals such as Clinical Endocrinology, Obesity and Fertility and Sterility and is on the editorial board for the Journal of Clinical Endocrinology and Metabolism. Dr. Sam is a teacher and mentor to medical students, residents and endocrinology fellows.


Eve Van Cauter, Ph.D.

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Emeritus Professor of Medicine
Section of Endocrinology and Metabolism
Department of Medicine

Dr. Van Cauter is an internationally known investigator in circadian rhythms on endocrine system in normal and pathological conditions. She is also an expert in the mathematical and statistical analysis of the temporal patterns of hormonal secretion and the effects of sleep on endocrine function. Dr. Van Cauter is the Principal Investigator of a Program Project which is focused on the age related changes in circadian rhythms.

Particularly interesting from a physiologic and therapeutic standpoint are studies which aim to investigate whether replacement of growth hormone in early sleep or restoration of elevated nocturnal melatonin levels, two hormonal events which are thought to act as internal synchronizers in young adults, may correct circadian rhythm alterations in older subjects. Dr. Van Cauter has also determined the utility of the use of hormonal rhythms as markers of the human circadian clock in basic studies examining the mechanisms of entrainment of hormonal rhythms, and their implication for adaptation to jet lag and shift work.

In addition, Dr. Van Cauter is one of five preceptors in the Northwestern University-University of Chicago NIH training grant for Sleep Research. Dr. Van Cauter has collaborated closely with Dr. Polonsky to define the role of ultradian and diurnal hormonal rhythms in glucose regulation. In recent years, she has led a major research program evaluating the impact of sleep loss on endocrine and metabolic function and the possible endocrine benefits of improved sleep quality in older adults.


Lisa Medalie, Psy.D., CBSM

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Clinical Associate of Psychiatry
Department of Psychiatry

Lisa Medalie, PsyD, CBSM, specializes in caring for children and adults with sleep disorders. She has a particular interest in treating insomnia. Dr. Medalie works with patients to create individualized treatment plans and teaches behavioral modification tools to help patients get a good night’s sleep. Dr. Medalie is a clinical psychologist with specialty training and certification in behavioral sleep medicine.

In addition, Dr. Medalie is actively involved in training interns and fellows in behavioral sleep medicine.


Harry Whitmore, RPSGT

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Chief Sleep Research Technologist